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Title: Highly Efficient Supramolecular Aggregation-Induced Emission-Active Pseudorotaxane Luminogen for Functional Bioimaging
Authors: Liow, Sing Shy
Zhou, Hui
Sugiarto, Sigit
Guo, Shifeng
Chalasani, Madhavi Latha S.
Verma, Navin Kumar
Xu, Jianwei
Loh, Xian Jun
Keywords: Aggregation-induced emissions
Host guest complexes
Issue Date: 2017
Source: Liow, S. S., Zhou, H., Sugiarto, S., Guo, S., Chalasani, M. L. S., Verma, N. K., et al. (2017). Highly Efficient Supramolecular Aggregation-Induced Emission-Active Pseudorotaxane Luminogen for Functional Bioimaging. Biomacromolecules, 18(3), 886-897.
Series/Report no.: Biomacromolecules
Abstract: The direct tracking of cells using fluorescent dyes is a constant challenge in cell therapy due to aggregation-induced quenching (ACQ) effect and biocompatibility issues. Here, we demonstrate the development of a biocompatible and highly efficient aggregation-induced emission (AIE)-active pseudorotaxane luminogen based on tetraphenylethene conjugated poly(ethylene glycol) (TPE-PEG2) (guest) and α-cyclodextrin (α-CD) (host). It is capable of showing significant fluorescent emission enhancement at the 400-600 nm range when excited at 388 nm, without increasing the concentration of AIE compound. The fluorescent intensity of TPE-PEG2 solution was effectively enhanced by 4-12 times with gradual addition of 1-4 mM of α-CD. 2D NOSEY 1H NMR revealed clear correlation spots between the characteristic peaks of α-CD and PEG, indicating the interaction between protons of ethylene glycol and cyclodextrin, and the structures are mainly based on threaded α-CD. The host-guest complex exhibits boosted fluorescent emission because the PEG side chains are confined in "nano-cavities" (host), thus, applying additional restriction on intermolecular rotation of TPE segments. In vitro cell experiments demonstrated the potential of AIE-active pseudorotaxane polymer as a biocompatible bioimaging probe.
ISSN: 1525-7797
DOI: 10.1021/acs.biomac.6b01777
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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