Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83643
Title: The Immunosenescence of αβ & γδ T cells in human blood and skin
Authors: Xu, Weili
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2019
Source: Xu, W. (2019). The Immunosenescence of αβ & γδ T cells in human blood and skin. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Studies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells have been neglected despite their role in immunosurveillance. In this thesis, we showed that peripheral Vδ2+ are differentially susceptible to life-long stresses as compared to other αβ and γδ T cells. Using aging, cytomegalovirus history as immunological models and via the different functional assays, we show that Vδ2+ T cells are protected from cellular senescence. Next, we also investigated the skin-resident T cells and show that they are also differentially susceptible to life-long stresses as compared to periphery T cells. In conclusion, this shows that not all immune cells in the host undergo similar process of immunosenescence and the underlying biology and mechanisms behind Vδ2+ and skin-resident T cells’ protection from cellular senescence with age could be exploited as possible interventions to other cell types or by itself to mitigate the “grey tsunami”.
URI: https://hdl.handle.net/10356/83643
http://hdl.handle.net/10220/47613
DOI: 10.32657/10220/47613
Schools: School of Biological Sciences 
Organisations: A*STAR Singapore Immunology Network
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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