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https://hdl.handle.net/10356/83719
Title: | A High-performance compact photoacoustic tomography system for in vivo small-animal brain imaging | Authors: | Upputuri, Paul Kumar Periyasamy, Vijitha Kalva, Sandeep Kumar Pramanik, Manojit |
Keywords: | Photoacoustic tomography Biomedical imaging |
Issue Date: | 2017 | Source: | Upputuri, P. K., Periyasamy, V., Kalva, S. K., & Pramanik, M. (2017). A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging. Journal of Visualized Experiments, (124), e55811-. | Series/Report no.: | Journal of Visualized Experiments | Abstract: | In vivo small-animal imaging has an important role to play in preclinical studies. Photoacoustic tomography (PAT) is an emerging hybrid imaging modality that shows great potential for both preclinical and clinical applications. Conventional optical parametric oscillator-based PAT (OPO-PAT) systems are bulky and expensive and cannot provide high-speed imaging. Recently, pulsed-laser diodes (PLDs) have been successfully demonstrated as an alternative excitation source for PAT. Pulsed-laser diode PAT (PLD-PAT) has been successfully demonstrated for high-speed imaging on photoacoustic phantoms and biological tissues. This work provides a visualized experimental protocol for in vivo brain imaging using PLD-PAT. The protocol includes the compact PLD-PAT system configuration and its description, animal preparation for brain imaging, and a typical experimental procedure for 2D cross-sectional rat brain imaging. The PLD-PAT system is compact and cost-effective and can provide high-speed, high-quality imaging. Brain images collected in vivo at various scan speeds are presented. | URI: | https://hdl.handle.net/10356/83719 http://hdl.handle.net/10220/43771 |
DOI: | 10.3791/55811 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2017 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: [http://dx.doi.org/10.3791/55811]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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A High-performance compact photoacoustic tomography system for in vivo small-animal brain imaging.pdf | 714.71 kB | Adobe PDF | View/Open |
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