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Title: Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma
Authors: Yates, Katherine P.
McGeachie, Michael J.
Zhou, Xiaobo
Guo, Feng
Sternberg, Alice L.
Van Natta, Mark L.
Wise, Robert A.
Szefler, Stanley J.
Sharma, Sunita
Kho, Alvin T.
Cho, Michael H.
Croteau-Chonka, Damien C.
Castaldi, Peter J.
Jain, Gaurav
Sanyal, Amartya
Zhan, Ye
Lajoie, Bryan R.
Dekker, Job
Stamatoyannopoulos, John
Covar, Ronina A.
Zeiger, Robert S.
Adkinson, N. Franklin
Williams, Paul V.
Kelly, H. William
Grasemann, Hartmut
Vonk, Judith M.
Koppelman, Gerard H.
Postma, Dirkje S.
Raby, Benjamin A.
Houston, Isaac
Lu, Quan
Fuhlbrigge, Anne L.
Tantisira, Kelan G.
Silverman, Edwin K.
Tonascia, James
Strunk, Robert C.
Weiss, Scott T.
Keywords: CSMD3
Issue Date: 2016
Source: McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., et al. (2016). Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. American Journal of Respiratory and Critical Care Medicine, 194(12), 1465-1474.
Series/Report no.: American Journal of Respiratory and Critical Care Medicine
Abstract: Rationale: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease. Objectives: To determine the genetic underpinnings of lung function patterns in subjects with childhood asthma. Methods: We performed a genome-wide association study of 581 non-Hispanic white individuals with asthma that were previously classified by patterns of lung function growth and decline (normal growth, normal growth with early decline, reduced growth, and reduced growth with early decline). The strongest association was also measured in two additional cohorts: a small asthma cohort and a large chronic obstructive pulmonary disease metaanalysis cohort. Interaction between the genomic region encompassing the most strongly associated single-nucleotide polymorphism and nearby genes was assessed by two chromosome conformation capture assays. Conclusions: Early decline in lung function after normal growth is associated with a genetic polymorphism that may also protect against early decline in reduced growth groups.
ISSN: 1073-449X
DOI: 10.1164/rccm.201602-0250OC
Schools: School of Biological Sciences 
Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2016 American Thoracic Society (ATS). This is the author created version of a work that has been peer reviewed and accepted for publication by American Journal of Respiratory and Critical Care Medicine, American Thoracic Society (ATS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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