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Title: Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions
Authors: Cao, Fan
Fang, Yiwen
Tan, Hong Kee
Goh, Yufen
Choy, Jocelyn Yeen Hui
Koh, Bryan Thean Howe
Hao Tan, Jiong
Bertin, Nicolas
Ramadass, Aroul
Hunter, Ewan
Green, Jayne
Salter, Matthew
Akoulitchev, Alexandre
Wang, Wilson
Chng, Wee Joo
Tenen, Daniel G.
Fullwood, Melissa Jane
Keywords: Chronic myeloid leukaemia
Genome informatics
Issue Date: 2017
Source: Cao, F., Fang, Y., Tan, H. K., Goh, Y., Choy, J. Y. H., Koh, B. T. H., et al. (2017). Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions. Scientific Reports, 7, 2186-.
Series/Report no.: Scientific Reports
Abstract: Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhancers that overlap with broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes. Besides cell lines, we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human samples. Several chromatin interactions involving super-enhancers and broad H3K4me3 domains are constitutive and can be found in both cancer and normal samples. Taken together, these results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-02257-3
Schools: School of Biological Sciences 
Rights: © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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