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Title: Surface characteristics and antimicrobial properties of modified catheter surfaces by polypyrogallol and metal ions
Authors: Balne, Praveen Kumar
Harini, Sriram
Dhand, Chetna
Dwivedi, Neeraj
Chalasani, Madhavi Latha Somaraju
Verma, Navin Kumar
Barathi, Veluchamy Amutha
Beuerman, Roger
Agrawal, Rupesh
Lakshminarayanan, Rajamani
Keywords: Catheter coating
Issue Date: 2018
Source: Balne, P. K., Harini, S., Dhand, C., Dwivedi, N., Chalasani, M. L. S., Verma, N. K., et al. (2018). Surface characteristics and antimicrobial properties of modified catheter surfaces by polypyrogallol and metal ions. Materials Science and Engineering: C, 90, 673-684.
Series/Report no.: Materials Science and Engineering: C
Abstract: Catheter associated infections (CAIs) are the major cause of nosocomial infections leading to increased morbidity, mortality rates and economical loss. Though the antibiotic coated surface modified catheters are reported to be effective in preventing CAIs, presence of sub-lethal concentrations of antibiotics in long term instilled catheters poses a risk of development and spread of drug resistant microbial strains. Herein, we have developed an antibiotic-free alternative strategy to coat catheter surfaces using pyrogallol (PG) and metal ions (Ag+/Mg2+). Surface characteristics, antimicrobial and anti-biofilm properties with hemocompatibility of the coated catheters were studied. Structural characteristics of coated catheters were similar to the uncoated catheters with improved wettability. All the coated catheters with PG and different PG/metal ion combinations exhibited broad spectrum antibacterial activity. Catheters coated with PG/metal ions combination showed effective antibiofilm properties against MRSA strains. None of the coated catheters showed any significant hemolysis for rabbit erythrocytes. In addition, polypyrogallol (pPG) coating attenuated the hemolytic properties of silver without altering the antimicrobial properties. The inherent antimicrobial properties of the coating agent along with antimicrobial metal ions broaden the application landscape which includes coating of other medical devices, clean room construction and development of antimicrobial surfaces. The chemical formulation can also be used to design antiseptic solutions to prevent healthcare associated infections.
ISSN: 0928-4931
DOI: 10.1016/j.msec.2018.04.095
Rights: © 2018 Published by Elsevier B.V. This paper was published in Materials Science and Engineering: C and is made available as an electronic reprint (preprint) with permission of Elsevier B.V. The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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