Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/83794
Title: | The gut microbiota influences blood-brain barrier permeability in mice | Authors: | Braniste, Viorica Al-Asmakh, Maha Kowal, Czeslawa Anuar, Farhana Abbaspour, Afrouz Tóth, Miklós Korecka, Agata Bakocevic, Nadja Ng, Lai Guan Kundu, Parag Gulyás, Balázs Halldin, Christer Hultenby, Kjell Nilsson, Harriet Hebert, Hans Volpe, Bruce T. Diamond, Betty Pettersson, Sven |
Keywords: | Blood brain barrier Microbiota |
Issue Date: | 2014 | Source: | Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Toth, M., et al. (2014). The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine, 6(263), 263ra158-. | Series/Report no.: | Science Translational Medicine | Abstract: | Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota–BBB communication is initiated during gestation and propagated throughout life. | URI: | https://hdl.handle.net/10356/83794 http://hdl.handle.net/10220/41486 |
ISSN: | 1946-6234 | DOI: | 10.1126/scitranslmed.3009759 | Rights: | © 2014 American Association for the Advancement of Science. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | LKCMedicine Journal Articles SCELSE Journal Articles |
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