Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83803
Title: A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy
Authors: Huang, Shuo
Upputuri, Paul Kumar
Liu, Hui
Pramanik, Manojit
Wang, Mingfeng
Keywords: Nanoparticle
Theranostic agents
Issue Date: 2016
Source: Huang, S., Upputuri, P. K., Liu, H., Pramanik, M., & Wang, M. (2016). A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy. Journal of Materials Chemistry B, 4(9), 1696-1703.
Series/Report no.: Journal of Materials Chemistry B
Abstract: It is essential to monitor and understand the diseased tissue before starting the treatments. Recently, many efforts have been devoted to explore theranostic agents that encapsulate therapeutic agents and diagnostic probes into one package. However, these physically mixed two agents may slowly dissociate from the carrier at different rates during the circulation in blood, leading to quite different biodistribution and pharmacokinetics. Thus, it is important to explore a photothermal agent which itself can serve as a contrast agent. Though some inorganic dual functional theranostic agents such as gold nanoparticles have been explored, most of them still suffer from poor biodegradability and biocompatibility. Herein, we report a theranostic agent based on a narrow-­‐bandgap small molecule, benzo[1,2-c;4,5-c’]bis[1,2,5]thiadiazole-4,7-bis(9,9-dioctyl-9H-­fluoren-­2-yl)thiophene (denoted as BBT-2FT), with strong absorption of near infrared (NIR) light. Colloidal nanoparticles composed of BBT­‐2FT show photoacoustic signal intensity 10 times higher than that of blood, and high photothermal conversion efficiency (η=40%) under irradiation of 800-nm laser light that kills over 90% HeLa cells in 10 mins.
URI: https://hdl.handle.net/10356/83803
http://hdl.handle.net/10220/41475
ISSN: 2050-750X
DOI: 10.1039/C5TB02367J
Rights: © 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Materials Chemistry B, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5TB02367J].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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