Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83803
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dc.contributor.authorHuang, Shuoen
dc.contributor.authorUpputuri, Paul Kumaren
dc.contributor.authorLiu, Huien
dc.contributor.authorPramanik, Manojiten
dc.contributor.authorWang, Mingfengen
dc.date.accessioned2016-09-22T07:09:50Zen
dc.date.accessioned2019-12-06T15:32:23Z-
dc.date.available2016-09-22T07:09:50Zen
dc.date.available2019-12-06T15:32:23Z-
dc.date.issued2016en
dc.identifier.citationHuang, S., Upputuri, P. K., Liu, H., Pramanik, M., & Wang, M. (2016). A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy. Journal of Materials Chemistry B, 4(9), 1696-1703.en
dc.identifier.issn2050-750Xen
dc.identifier.urihttps://hdl.handle.net/10356/83803-
dc.description.abstractIt is essential to monitor and understand the diseased tissue before starting the treatments. Recently, many efforts have been devoted to explore theranostic agents that encapsulate therapeutic agents and diagnostic probes into one package. However, these physically mixed two agents may slowly dissociate from the carrier at different rates during the circulation in blood, leading to quite different biodistribution and pharmacokinetics. Thus, it is important to explore a photothermal agent which itself can serve as a contrast agent. Though some inorganic dual functional theranostic agents such as gold nanoparticles have been explored, most of them still suffer from poor biodegradability and biocompatibility. Herein, we report a theranostic agent based on a narrow-­‐bandgap small molecule, benzo[1,2-c;4,5-c’]bis[1,2,5]thiadiazole-4,7-bis(9,9-dioctyl-9H-­fluoren-­2-yl)thiophene (denoted as BBT-2FT), with strong absorption of near infrared (NIR) light. Colloidal nanoparticles composed of BBT­‐2FT show photoacoustic signal intensity 10 times higher than that of blood, and high photothermal conversion efficiency (η=40%) under irradiation of 800-nm laser light that kills over 90% HeLa cells in 10 mins.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent8 p.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Materials Chemistry Ben
dc.rights© 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Materials Chemistry B, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C5TB02367J].en
dc.subjectNanoparticleen
dc.subjectTheranostic agentsen
dc.titleA dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapyen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.identifier.doi10.1039/C5TB02367Jen
dc.description.versionAccepted versionen
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