Please use this identifier to cite or link to this item:
Title: Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
Authors: Cho, Nam-Joon
Lee, Choongho
Pang, Phillip S.
Pham, Edward A.
Fram, Benjamin
Nguyen, Khanh
Xiong, Anming
Sklan, Ella H.
Elazar, Menashe
Koytak, Elif S.
Kersten, Caroline
Kanazawa, Kay K.
Frank, Curtis W.
Glenn, Jeffrey S.
Keywords: Antiviral Strategies
Signaling Molecule
Issue Date: 2015
Source: Cho, N. J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., Xiong, A., Sklan, E. H., Elazar, M., Koytak, E. S., Kersten, C., Kanazawa, K. K., Frank, C. W., & Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616-625.
Series/Report no.: Gastroenterology
Abstract: Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle.
ISSN: 00165085
DOI: 10.1053/j.gastro.2014.11.043
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles


Updated on Jul 13, 2020

Citations 50

Updated on Nov 30, 2020

Page view(s) 50

Updated on Dec 3, 2020

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.