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dc.contributor.authorCho, Nam-Joonen
dc.contributor.authorLee, Choonghoen
dc.contributor.authorPang, Phillip S.en
dc.contributor.authorPham, Edward A.en
dc.contributor.authorFram, Benjaminen
dc.contributor.authorNguyen, Khanhen
dc.contributor.authorXiong, Anmingen
dc.contributor.authorSklan, Ella H.en
dc.contributor.authorElazar, Menasheen
dc.contributor.authorKoytak, Elif S.en
dc.contributor.authorKersten, Carolineen
dc.contributor.authorKanazawa, Kay K.en
dc.contributor.authorFrank, Curtis W.en
dc.contributor.authorGlenn, Jeffrey S.en
dc.identifier.citationCho, N. J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., Xiong, A., Sklan, E. H., Elazar, M., Koytak, E. S., Kersten, C., Kanazawa, K. K., Frank, C. W., & Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616-625.en
dc.description.abstractPhosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.subjectAntiviral Strategiesen
dc.subjectSignaling Moleculeen
dc.titlePhosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genomeen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
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