Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/83833
Title: | Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome | Authors: | Cho, Nam-Joon Lee, Choongho Pang, Phillip S. Pham, Edward A. Fram, Benjamin Nguyen, Khanh Xiong, Anming Sklan, Ella H. Elazar, Menashe Koytak, Elif S. Kersten, Caroline Kanazawa, Kay K. Frank, Curtis W. Glenn, Jeffrey S. |
Keywords: | Antiviral Strategies Signaling Molecule QCM |
Issue Date: | 2015 | Source: | Cho, N. J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., Xiong, A., Sklan, E. H., Elazar, M., Koytak, E. S., Kersten, C., Kanazawa, K. K., Frank, C. W., & Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616-625. | Series/Report no.: | Gastroenterology | Abstract: | Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle. | URI: | https://hdl.handle.net/10356/83833 http://hdl.handle.net/10220/41454 |
ISSN: | 00165085 | DOI: | 10.1053/j.gastro.2014.11.043 | Schools: | School of Materials Science & Engineering | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MSE Journal Articles |
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