Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83864
Title: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Authors: Warren, Helen R
Evangelou, Evangelos
Cabrera, Claudia P
Gao, He
Ren, Meixia
Mifsud, Borbala
Ntalla, Ioanna
Surendran, Praveen
Liu, Chunyu
Cook, James P
Kraja, Aldi T
Drenos, Fotios
Loh, Marie
Verweij, Niek
Marten, Jonathan
Karaman, Ibrahim
Lepe, Marcelo P Segura
O'Reilly, Paul F
Knight, Joanne
Snieder, Harold
Kato, Norihiro
He, Jiang
Tai, E Shyong
Said, M Abdullah
Porteous, David
Alver, Maris
Poulter, Neil
Farrall, Martin
Gansevoort, Ron T
Padmanabhan, Sandosh
Mägi, Reedik
Stanton, Alice
Connell, John
Bakker, Stephan J L
Metspalu, Andres
Shields, Denis C
Thom, Simon
Brown, Morris
Sever, Peter
Esko, Tõnu
Hayward, Caroline
van der Harst, Pim
Saleheen, Danish
Chowdhury, Rajiv
Chasman, Daniel I
Chakravarti, Aravinda
Newton-Cheh, Christopher
Lindgren, Cecilia M
Levy, Daniel
Kooner, Jaspal S
Keavney, Bernard
Tomaszewski, Maciej
Samani, Nilesh J
Howson, Joanna M M
Tobin, Martin D
Munroe, Patricia B
Ehret, Georg B
Wain, Louise V
Wain, Louise V
Vaez, Ahmad
Jansen, Rick
Joehanes, Roby
van der Most, Peter J
Erzurumluoglu, A Mesut
O'Reilly, Paul
Cabrera, Claudia P
Warren, Helen R
Rose, Lynda M
Verwoert, Germaine C
Hottenga, Jouke-Jan
Strawbridge, Rona J
Esko, Tonu
Arking, Dan E
Hwang, Shih-Jen
Guo, Xiuqing
Kutalik, Zoltan
Trompet, Stella
Shrine, Nick
Teumer, Alexander
Ried, Janina S
Bis, Joshua C
Smith, Albert V
Amin, Najaf
Nolte, Ilja M
Lyytikäinen, Leo-Pekka
Mahajan, Anubha
Wareham, Nicholas J
Hofer, Edith
Joshi, Peter K
Kristiansson, Kati
Traglia, Michela
Havulinna, Aki S
Goel, Anuj
Nalls, Mike A
Sõber, Siim
Vuckovic, Dragana
Luan, Jian'an
M, Fabiola Del Greco
Ayers, Kristin L
Marrugat, Jaume
Ruggiero, Daniela
Lopez, Lorna M
Niiranen, Teemu
Enroth, Stefan
Jackson, Anne U
Nelson, Christopher P
Huffman, Jennifer E
Zhang, Weihua
Marten, Jonathan
Gandin, Ilaria
Harris, Sarah E
Zemonik, Tatijana
Lu, Yingchang
Evangelou, Evangelos
Shah, Nabi
de Borst, Martin H
Mangino, Massimo
Prins, Bram P
Campbell, Archie
Li-Gao, Ruifang
Chauhan, Ganesh
Oldmeadow, Christopher
Abecasis, Gonçalo
Abedi, Maryam
Barbieri, Caterina M
Barnes, Michael R
Batini, Chiara
Blake, Tineka
Boehnke, Michael
Bottinger, Erwin P
Braund, Peter S
Brown, Morris
Brumat, Marco
Campbell, Harry
Chambers, John Campbell
Cocca, Massimiliano
Collins, Francis
Connell, John
Cordell, Heather J
Damman, Jeffrey J
Davies, Gail
de Geus, Eco J
de Mutsert, Renée
Deelen, Joris
Demirkale, Yusuf
Doney, Alex S F
Dörr, Marcus
Farrall, Martin
Ferreira, Teresa
Frånberg, Mattias
Giedraitis, Vilmantas
Gao, He
Gieger, Christian
Giulianini, Franco
Gow, Alan J
Hamsten, Anders
Harris, Tamara B
Hofman, Albert
Holliday, Elizabeth G
Jarvelin, Marjo-Riitta
Johansson, Åsa
Johnson, Andrew D
Jousilahti, Pekka
Jula, Antti
Kähönen, Mika
Kathiresan, Sekar
Khaw, Kay-Tee
Kolcic, Ivana
Koskinen, Seppo
Langenberg, Claudia
Larson, Marty
Launer, Lenore J
Lehne, Benjamin
Liewald, David C M
Lin, Li
Lind, Lars
Mach, François
Mamasoula, Chrysovalanto
Menni, Cristina
Mifsud, Borbala
Milaneschi, Yuri
Morgan, Anna
Morris, Andrew D
Morrison, Alanna C
Munson, Peter J
Nandakumar, Priyanka
Nguyen, Quang Tri
Nutile, Teresa
Oldehinkel, Albertine J
Oostra, Ben A
Org, Elin
Padmanabhan, Sandosh
Palotie, Aarno
Paré, Guillaume
Pattie, Alison
Penninx, Brenda W J H
Poulter, Neil
Pramstaller, Peter P
Raitakari, Olli T
Ren, Meixia
Rice, Kenneth
Ridker, Paul M
Riese, Harriëtte
Ripatti, Samuli
Robino, Antonietta
Rotter, Jerome I
Rudan, Igor
Saba, Yasaman
Pierre, Aude Saint
Sala, Cinzia F
Sarin, Antti-Pekka
Schmidt, Reinhold
Scott, Rodney
Seelen, Marc A
Shields, Denis C
Siscovick, David
Sorice, Rossella
Stanton, Alice
Stott, David J
Sundström, Johan
Swertz, Morris
Taylor, Kent D
Thom, Simon
Tzoulaki, Ioanna
Tzourio, Christophe
Uitterlinden, André G
Völker, Uwe
Vollenweider, Peter
Wild, Sarah
Willemsen, Gonneke
Hartman, Catharina A
Wright, Alan F
Yao, Jie
Thériault, Sébastien
Conen, David
John, Attia
Sever, Peter
Debette, Stéphanie
Mook-Kanamori, Dennis O
Zeggini, Eleftheria
Spector, Tim D
van der Harst, Pim
Palmer, Colin N A
Vergnaud, Anne-Claire
Loos, Ruth J F
Polasek, Ozren
Starr, John M
Girotto, Giorgia
Hayward, Caroline
Kooner, Jaspal S
Lindgren, Cecila M
Vitart, Veronique
Samani, Nilesh J
Tuomilehto, Jaakko
Watkins, Hugh
Gyllensten, Ulf
Knekt, Paul
Deary, Ian J
Ciullo, Marina
Elosua, Roberto
Keavney, Bernard D
Hicks, Andrew A
Scott, Robert A
Gasparini, Paolo
Laan, Maris
Liu, YongMei
Salomaa, Veikko
Toniolo, Daniela
Perola, Markus
Wilson, James F
Schmidt, Helena
Zhao, Jing Hua
Lehtimäki, Terho
van Duijn, Cornelia M
Gudnason, Vilmundur
Psaty, Bruce M
Peters, Annette
Rettig, Rainer
James, Alan
Jukema, J Wouter
Strachan, David P
Palmas, Walter
Metspalu, Andres
Ingelsson, Erik
Boomsma, Dorret I
Franco, Oscar H
Bochud, Murielle
Newton-Cheh, Christopher
Munroe, Patricia B
Elliott, Paul
Chasman, Daniel I
Chakravarti, Aravinda
Knight, Joanne
Morris, Andrew P
Levy, Daniel
Tobin, Martin D
Snieder, Harold
Caulfield, Mark J
Ehret, Georg B
Barnes, Michael R
Tzoulaki, Ioanna
Caulfield, Mark J
Elliott, Paul
Keywords: Cardiovascular Risk
Blood Pressure
Issue Date: 2017
Source: Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., et al. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 49(3), 403-415.
Series/Report no.: Nature Genetics
Abstract: Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early
URI: https://hdl.handle.net/10356/83864
http://hdl.handle.net/10220/42921
ISSN: 1061-4036
DOI: 10.1038/ng.3768
Rights: © 2017 Nature America, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature Genetics, Nature America, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1038/ng.3768].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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