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Title: Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelialization
Authors: Hu, Benhui
Leow, Wan Ru
Amini, Shahrouz
Nai, Brenda
Zhang, Xiaoqian
Liu, Zhiyuan
Cai, Pingqiang
Li, Zhuyun
Wu, Yun-Long
Miserez, Ali
Lim, Chwee Teck
Chen, Xiaodong
Keywords: Epithelial bridge
Migration patterns
Issue Date: 2017
Source: Hu, B., Leow, W. R., Amini, S., Nai, B., Zhang, X., Liu, Z., et al. (2017). Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelialization. Advanced Materials, in press.
Series/Report no.: Advanced Materials
Abstract: Re-epithelialization by collective migration of epithelial cells over a heterogeneous environment to restore tissue integrity and functions is critical for development and regeneration. Here, it is reported that the spatial organization of adjacent adherent paths within sparsely distributed extracellular matrix (ECM) has a significant impact on the orientational coupling between cell polarization and collective cell migration. This coupling effect determines the migration pattern for human keratinocytes to regain their cohesion, which impacts the occupancy of epithelial bridge and the migration velocity in wound repair. Statistical studies suggest the converging organization of ECM, in which adjacent paths become closer to each other and finally converge to a junctional point, facilitating collective cell migration mostly within variable ECM organization, as the polarization of the advancing cell sheet is remodeled to align along the direction of cell migration. The findings may help to design implantable ECM to optimize efficient skin regeneration.
ISSN: 0935-9648
DOI: 10.1002/adma.201700145
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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