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Title: Microsphere enabled subdiffraction-limited optical-resolution photoacoustic microscopy: a simulation study
Authors: Upputuri, Paul Kumar
Krisnan, Moganasundari
Pramanik, Manojit
Keywords: Photoacoustics
Issue Date: 2016
Source: Upputuri, P. K., Krisnan, M., & Pramanik, M. (2017). Microsphere enabled subdiffraction-limited optical-resolution photoacoustic microscopy: a simulation study. Journal of Biomedical Optics, 22(4), 045001-.
Series/Report no.: Journal of Biomedical Optics
Abstract: Optical resolution photoacoustic microscopy (ORPAM) is a high-resolution hybrid imaging modality having potential for microscale in vivo imaging. Optical diffraction limits the lateral resolution of ORPAM. A photonic nanojet (PNJ) was used to break this diffraction limit. A single round microsphere can generate a PNJ with subwavelength waist, but its short axial length limits its applications to surface imaging only. We investigate different sphere designs to achieve ultralong nanojets that will make the nanojet more viable in far-field applications, such as photoacoustic imaging. The PNJ properties, including effective length, waist size, working distance, and peak intensity, can be tuned and controlled by changing the sphere design and its refractive index. A truncated multilayer microsphere design could generate an ultraelongated PNJ with length larger than ∼172λ (∼138  μm) while retaining a large working distance ∼32λ (∼26  μm). Through simulation study, we observed ∼11-fold enhancement in lateral resolution with 5  μm round sphere (refractive index 2.2) when used in a conventional ORPAM setup with NA=0.1 and λ=800  nm.
ISSN: 1083-3668
DOI: 10.1117/1.JBO.22.4.045001
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2016 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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