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Title: Regulation of Stress Responses and Translational Control by Coronavirus
Authors: Liao, Ying
Fung, To Sing
Liu, Ding Xiang
Keywords: ER Stress
Issue Date: 2016
Source: Fung, T. S., Liao, Y., & Liu, D. X. (2016). Regulation of Stress Responses and Translational Control by Coronavirus. Viruses, 8(7), 184-.
Series/Report no.: Viruses
Abstract: Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.
ISSN: 1999-4915
DOI: 10.3390/v8070184
Schools: School of Biological Sciences 
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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