Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/83953
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dc.contributor.authorLiao, Yingen
dc.contributor.authorFung, To Singen
dc.contributor.authorLiu, Ding Xiangen
dc.date.accessioned2017-07-18T03:56:54Zen
dc.date.accessioned2019-12-06T15:35:16Z-
dc.date.available2017-07-18T03:56:54Zen
dc.date.available2019-12-06T15:35:16Z-
dc.date.issued2016en
dc.identifier.citationFung, T. S., Liao, Y., & Liu, D. X. (2016). Regulation of Stress Responses and Translational Control by Coronavirus. Viruses, 8(7), 184-.en
dc.identifier.issn1999-4915en
dc.identifier.urihttps://hdl.handle.net/10356/83953-
dc.description.abstractSimilar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent15 p.en
dc.language.isoenen
dc.relation.ispartofseriesVirusesen
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectER Stressen
dc.subjectCoronavirusen
dc.titleRegulation of Stress Responses and Translational Control by Coronavirusen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.3390/v8070184en
dc.description.versionPublished versionen
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