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Title: Human Coronaviruses: A Review of Virus–Host Interactions
Authors: Lim, Yvonne Xinyi
Ng, Yan Ling
Tam, James Pingkwan
Liu, Ding Xiang
Keywords: Human coronavirus
Virus–host interactions
Issue Date: 2016
Source: Lim, Y. X., Ng, Y. L., Tam, J. P., & Liu, D. X. (2016). Human Coronaviruses: A Review of Virus–Host Interactions. Diseases, 4(3), 26-.
Series/Report no.: Diseases
Abstract: Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in humans. The study of HCoV-host interactions has contributed extensively to our understanding of HCoV pathogenesis. In this review, we discuss some of the recent findings of host cell factors that might be exploited by HCoVs to facilitate their own replication cycle. We also discuss various cellular processes, such as apoptosis, innate immunity, ER stress response, mitogen-activated protein kinase (MAPK) pathway and nuclear factor kappa B (NF-κB) pathway that may be modulated by HCoVs.
DOI: 10.3390/diseases4030026
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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