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Title: G-quadruplex structure of an anti-proliferative DNA sequence
Authors: Do, Ngoc Quang
Chung, Wan Jun
Truong, Thi Hong Anh
Heddi, Brahim
Phan, Anh Tuân
Keywords: Cancer
Issue Date: 2017
Source: Do, N. Q., Chung, W. J., Truong, T. H. A., Heddi, B., & Phan, A. T. (2017). G-quadruplex structure of an anti-proliferative DNA sequence. Nucleic Acids Research, 45(12), 7487-7493.
Series/Report no.: Nucleic Acids Research
Abstract: AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti-proliferative activity as AGRO100. The solution structure of AT11 revealed a four-layer G-quadruplex comprising of two propeller-type parallel-stranded subunits connected through a central linker. The stacking between the two subunits occurs at the 3΄-end of the first block and the 5΄-end of the second block. The structure of the anti-proliferative DNA sequence AT11 will allow greater understanding on the G-quadruplex folding principles and aid in structural optimization of anti-proliferative oligonucleotides.
ISSN: 0305-1048
DOI: 10.1093/nar/gkx274
Schools: School of Biological Sciences 
School of Physical and Mathematical Sciences 
Rights: © 2017 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
Fulltext Permission: open
Fulltext Availability: With Fulltext
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