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Title: Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids
Authors: Polizzi, Arnaud
Fouché, Edwin
Ducheix, Simon
Lasserre, Frédéric
Marmugi, Alice P.
Mselli-Lakhal, Laila
Loiseau, Nicolas
Wahli, Walter
Guillou, Hervé
Montagner, Alexandra
Keywords: nuclear receptors
Issue Date: 2016
Source: Polizzi, A., Fouché, E., Ducheix, S., Lasserre, F., Marmugi, A., Mselli-Lakhal, L., et al. (2016). Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids. International Journal of Molecular Sciences, 17(10), 1624-.
Series/Report no.: International Journal of Molecular Sciences
Abstract: The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα(-/-) male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand.
ISSN: 1661-6596
DOI: 10.3390/ijms17101624
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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