Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/84065
Title: Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy
Authors: Tan, Sijie
Wong, Esther
Keywords: Mitophagy
Polyphenol
Issue Date: 2017
Source: Tan, S., & Wong, E. (2017). Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy. Oxidative Medicine and Cellular Longevity, 2017, 9028435-.
Series/Report no.: Oxidative Medicine and Cellular Longevity
Abstract: Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control. Upregulation of mitophagy has shown to mitigate superfluous mitochondrial accumulation and toxicity to safeguard mitochondrial fitness. Hence, mitophagy is a viable target to promote longevity and prevent age-related pathologies. Current challenge in modulating mitophagy for cellular protection involves identification of physiological ways to activate the pathway. Till date, mitochondrial stress and toxins remain the most potent inducers of mitophagy. Polyphenols have recently been demonstrated to protect mitochondrial health by facilitating mitophagy, thus suggesting the exciting prospect of augmenting mitophagy through dietary intake. In this review, we will first discuss the different surveillance mechanisms responsible for the removal of damaged mitochondrial components, followed by highlighting the transcriptional regulatory mechanisms of mitophagy. Finally, we will review the functional connection between polyphenols and mitophagy and provide insight into the underlying mechanisms that potentially govern polyphenol-induced mitophagy.
URI: https://hdl.handle.net/10356/84065
http://hdl.handle.net/10220/42930
ISSN: 1942-0900
DOI: 10.1155/2017/9028435
Rights: © 2017 Sijie Tan and Esther Wong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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