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Title: Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides
Authors: Koh, Phay Chung
Keywords: Antimicrobial peptide
Issue Date: 2016
Source: Koh, P. C. (2016, March). Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.
Abstract: Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours safety assessments of all the therapeutic peptides using appropriate biological model systems. Our collaborating group has developed a novel series of AMPs with broad spectrum antimicrobial activities. Aim: To examine possible cytotoxicity and immunogenicity (if any) of the four AMPs (Pep 1, Pep 2, Pep 3, & Pep 4) using cell culture model systems. [2nd Award]
Rights: © 2016 Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:URECA Posters

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