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Title: Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa
Authors: Simam, Joan
Rono, Martin
Ngoi, Joyce
Nyonda, Mary
Mok, Sachel
Marsh, Kevin
Bozdech, Zbynek
Mackinnon, Margaret
Keywords: Plasmodium Falciparum
Copy Number Variation
Issue Date: 2018
Source: Simam, J., Rono, M., Ngoi, J., Nyonda, M., Mok, S., Marsh, K., et al. (2018). Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa. BMC Genomics, 19(1), 372-.
Series/Report no.: BMC Genomics
Abstract: Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as red cell invasion, transmissibility and cytoadherence. Studies of natural parasite populations indicate that CNVs are also common in the field and thus may facilitate adaptation of the parasite to its local environment.
ISSN: 1471-2164
DOI: 10.1186/s12864-018-4689-7
Rights: © 2018 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles


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