Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/84319
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sottoriva, Andrea. | en |
dc.contributor.author | Sloot, Peter M. A. | en |
dc.contributor.author | Medema, Jan Paul. | en |
dc.contributor.author | Vermeulen, Louis. | en |
dc.date.accessioned | 2013-06-11T04:30:45Z | en |
dc.date.accessioned | 2019-12-06T15:42:42Z | - |
dc.date.available | 2013-06-11T04:30:45Z | en |
dc.date.available | 2019-12-06T15:42:42Z | - |
dc.date.copyright | 2010 | en |
dc.date.issued | 2010 | en |
dc.identifier.citation | Sottoriva, A., Sloot, P. M. A., Medema, J. P., & Vermeulen, L. (2010). Exploring cancer stem cell niche directed tumor growth. Cell Cycle, 9(8), 1472-1479. | en |
dc.identifier.uri | https://hdl.handle.net/10356/84319 | - |
dc.description.abstract | The finding that only a sub-fraction of tumor cells, so called Cancer Stem Cells (CSC), is endowed with the capacity to initiate new tumors has important consequences for fundamental as well as clinical cancer research. Previously we established by computational modeling techniques that CSC driven tumor growth instigates infiltrative behavior, and perhaps most interesting, stimulates tumor cell heterogeneity. An important question that remains is to what extend CSC functions are intrinsically regulated or whether this capacity is orchestrated by the microenvironment, i.e. a putative CSC niche. Here we investigate how extrinsic regulation of CSC properties affects the characteristics of malignancies. We find that highly invasive growth in tumors dependent on a small subset of cells is not restricted to CSC-driven tumors, but is also observed in tumors where the CSC capacity of tumor cells is completely defined by the microenvironment. Importantly, also the high level of heterogeneity that was observed for CSC-driven tumors is preserved and partially even increased in malignancies with a microenvironmentally orchestrated CSC population. This indicates that invasive growth and high heterogeneity are fundamental properties of tumors fueled by a small population of tumor cells. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Cell cycle | en |
dc.rights | © 2010 Landes Bioscience. | en |
dc.subject | DRNTU::Engineering::Computer science and engineering | en |
dc.title | Exploring cancer stem cell niche directed tumor growth | en |
dc.type | Journal Article | en |
dc.contributor.school | School of Computer Engineering | en |
dc.identifier.doi | 10.4161/cc.9.8.11198 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | SCSE Journal Articles |
SCOPUSTM
Citations
10
31
Updated on Mar 23, 2024
Web of ScienceTM
Citations
10
28
Updated on Oct 28, 2023
Page view(s) 20
695
Updated on Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.