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Title: Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression
Authors: Lyu, Yan
Cui, Dong
Sun, He
Miao, Yansong
Duan, Hongwei
Pu, Kanyi
Keywords: Dendronized semiconducting polymer
Gene carriers
Issue Date: 2017
Source: Lyu, Y., Cui, D., Sun, H., Miao, Y., Duan, H., & Pu, K. (2017). Dendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression. Angewandte Chemie International Edition, 56(31), 9155-9159.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-infrared (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription. Such a DSP-mediated remote activation can rapidly and safely result in 25- and 4.5-fold increases in the expression levels of proteins in living cells and mice, respectively. This study thus provides a promising approach to optically regulate transgene systems for on-demand therapeutic transgene dosing.
ISSN: 1433-7851
DOI: 10.1002/anie.201705543
Rights: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
SCBE Journal Articles

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