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Title: Recent advances in chitosan-based carriers for gene delivery
Authors: Cao, Ye
Tan, Yang Fei
Wong, Yee Shan
Liew, Melvin Wen Jie
Venkatraman, Subbu
Keywords: Engineering::Materials
Issue Date: 2019
Source: Cao, Y., Tan, Y. F., Wong, Y. S., Liew, M. W. J., & Venkatraman, S. (2019). Recent Advances in Chitosan-Based Carriers for Gene Delivery. Marine Drugs, 17(6), 381-. doi:10.3390/md17060381
Series/Report no.: Marine Drugs
Abstract: Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers.
ISSN: 1660-3397
DOI: 10.3390/md17060381
Rights: © 2019 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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