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Title: Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging
Authors: Xie, Chen
Upputuri, Paul Kumar
Zhen, Xu
Pramanik, Manojit
Pu, Kanyi
Keywords: Semiconducting polymer nanoparticles
Photoacoustic imaging
Issue Date: 2016
Source: Xie, C., Upputuri, P. K., Zhen, X., Pramanik, M., & Pu, K. (2016). Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging. Biomaterials, in press.
Series/Report no.: Biomaterials
Abstract: Development of photoacoustic (PA) imaging agents provides opportunities for advancing PA imaging in fundamental biology and medicine. Despite the promise of semiconducting polymer nanoparticles (SPNs) for PA imaging, the molecular guidelines to enhance their imaging performance are limited. In this study, semiconducting polymers (SPs) with self-quenched fluorescence are synthesized and transformed into SPNs for amplified PA imaging in living mice. The self-quenched process is induced by the incorporation of an electron-deficient structure unit into the backbone of SPs, which in turn promotes the nonradiative decay and enhances the heat generation. Such a simple chemical alteration of SP eventually leads to 1.7-fold PA amplification for the corresponding SPN. By virtue of the targeting capability of cyclic-RGD, the amplified SPN can effectively delineate tumor in living mice and increase the PA intensity of tumor by 4.7-fold after systemic administration. Our study thus provides an effective molecular guideline to amplify the PA brightness of organic imaging agents for in vivo PA imaging.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2016.12.004
Rights: © 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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