Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/84600
Title: Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
Authors: Fang, Yiwen
Fullwood, Melissa Jane
Keywords: lncRNAs
Chromatin
Issue Date: 2016
Source: Fang, Y., & Fullwood, M. J. (2016). Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics, Proteomics & Bioinformatics, 14(1), 42-54.
Series/Report no.: Genomics, Proteomics & Bioinformatics
Abstract: Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
URI: https://hdl.handle.net/10356/84600
http://hdl.handle.net/10220/41878
ISSN: 1672-0229
DOI: 10.1016/j.gpb.2015.09.006
Rights: © 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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