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Title: Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
Authors: Schäfer, Jürgen
Griese, Matthias
Chandrasekaran, Ravishankar
Chotirmall, Sanjay Haresh
Hartl, Dominik
Keywords: Bronchiectasis
Cystic Fibrosis
Issue Date: 2018
Source: Schäfer, J., Griese, M., Chandrasekaran, R., Chotirmall, S. H., & Hartl, D. (2018). Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis. BMC Pulmonary Medicine, 18(1), 79-.
Series/Report no.: BMC Pulmonary Medicine
Abstract: Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acquired conditions frequently featuring bronchiectasis include post-infective bronchiectasis and chronic obstructive pulmonary disease (COPD). Mechanistically, bronchiectasis is driven by a complex interplay of inflammation and infection with neutrophilic inflammation playing a predominant role. The clinical characterization and management of bronchiectasis should involve a precise diagnostic workup, tailored therapeutic strategies and pulmonary imaging that has become an essential tool for the diagnosis and follow-up of bronchiectasis. Prospective future studies are required to optimize the diagnostic and therapeutic management of bronchiectasis, particularly in heterogeneous non-CF bronchiectasis populations.
DOI: 10.1186/s12890-018-0630-8
Rights: © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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