Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/84964
Title: Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice
Authors: Tsuneoka, Yousuke
Tokita, Kenichi
Yoshihara, Chihiro
Amano, Taiju
Esposito, Gianluca
Huang, Arthur J.
Yu, Lily M. Y.
Odaka, Yuri
Shinozuka, Kazutaka
McHugh, Thomas J .
Kuroda, Kumi O.
Keywords: Fatherhood
Maternal behavior
Issue Date: 2015
Source: Tsuneoka, Y., Tokita, K., Yoshihara, C., Amano, T., Esposito, G., Huang, A. J., et al. (2015). Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice. The EMBO Journal, 34(21), 2652-2670.
Series/Report no.: The EMBO Journal
Abstract: Paternal behavior is not innate but arises through social experience. After mating and becoming fathers, male mice change their behavior toward pups from infanticide to paternal care. However, the precise brain areas and circuit mechanisms connecting these social behaviors are largely unknown. Here we demonstrated that the c‐Fos expression pattern in the four nuclei of the preoptic‐bed nuclei of stria terminalis (BST) region could robustly discriminate five kinds of previous social behavior of male mice (parenting, infanticide, mating, inter‐male aggression, solitary control). Specifically, neuronal activation in the central part of the medial preoptic area (cMPOA) and rhomboid nucleus of the BST (BSTrh) retroactively detected paternal and infanticidal motivation with more than 95% accuracy. Moreover, cMPOA lesions switched behavior in fathers from paternal to infanticidal, while BSTrh lesions inhibited infanticide in virgin males. The projections from cMPOA to BSTrh were largely GABAergic. Optogenetic or pharmacogenetic activation of cMPOA attenuated infanticide in virgin males. Taken together, this study identifies the preoptic‐BST nuclei underlying social motivations in male mice and reveals unexpected complexity in the circuit connecting these nuclei.
URI: https://hdl.handle.net/10356/84964
http://hdl.handle.net/10220/42040
ISSN: 0261-4189
DOI: 10.15252/embj.201591942
Rights: © 2015 The Authors. This is the author created version of a work that has been peer reviewed and accepted for publication in The EMBO Journal, published by European Molecular Biology Organization (EMBO) on behalf of the authors. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.15252/embj.201591942].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles

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