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dc.contributor.authorWilliams, Rohan B. H.en
dc.contributor.authorChen, Swaine L.en
dc.contributor.authorDunny, Gary M.en
dc.contributor.authorKline, Kimberly A.en
dc.contributor.authorKeogh, Damienen
dc.contributor.authorTay, Wei Hongen
dc.contributor.authorHo, Yao Yongen
dc.contributor.authorDale, Jennifer L.en
dc.contributor.authorChen, Siyien
dc.contributor.authorUmashankar, Shivshankaren
dc.identifier.citationKeogh, D., Tay, W. H., Ho, Y. Y., Dale, J. L., Chen, S., Umashankar, S., et al. (2016). Enterococcal Metabolite Cues Facilitate Interspecies Niche Modulation and Polymicrobial Infection. Cell Host & Microbe, 20(4), 493-503.en
dc.description.abstractEnterococcus faecalis is frequently associated with polymicrobial infections of the urinary tract, indwelling catheters, and surgical wound sites. E. faecalis co-exists with Escherichia coli and other pathogens in wound infections, but mechanisms that govern polymicrobial colonization and pathogenesis are poorly defined. During infection, bacteria must overcome multiple host defenses, including nutrient iron limitation, to persist and cause disease. In this study, we investigated the contribution of E. faecalis to mixed-species infection when iron availability is restricted. We show that E. faecalis significantly augments E. coli biofilm growth and survival in vitro and in vivo by exporting L-ornithine. This metabolic cue facilitates E. coli biosynthesis of the enterobactin siderophore, allowing E. coli growth and biofilm formation in iron-limiting conditions that would otherwise restrict its growth. Thus, E. faecalis modulates its local environment by contributing growth-promoting cues that allow co-infecting organisms to overcome iron limitation and promotes polymicrobial infections.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent40 p.en
dc.relation.ispartofseriesCell Host & Microbeen
dc.rights© 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Cell Host & Microbe, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subjectPolymicrobial infectionen
dc.titleEnterococcal Metabolite Cues Facilitate Interspecies Niche Modulation and Polymicrobial Infectionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.organizationSingapore Centre for Environmental Life Sciences Engineeringen
dc.description.versionAccepted versionen
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