Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85134
Title: Functional connectivity of resting-state, working memory and inhibition networks in perceived stress
Authors: Archer, Jo A.
Lee, Annie
Qiu, Anqi
Chen, Annabel Shen-Hsing
Keywords: Functional magnetic resonance imaging
Functional connectivity
Perceived stress
DRNTU::Science::Medicine
Issue Date: 2017
Source: Archer, J. A., Lee, A., Qiu, A., & Annabel Chen, S. H. (2017). Functional connectivity of resting-state, working memory and inhibition networks in perceived stress. Neurobiology of Stress, 8, 186-201. doi: 10.1016/j.ynstr.2017.01.002.
Series/Report no.: Neurobiology of Stress
Abstract: Experimental imaging studies on the effects of acute stress have revealed functional changes in the amygdalae, hippocampi and medial frontal cortices. However, much less is known about the association between perceived stress and neurological function which may have implications for the development of stress related disorders. Participants completed a working-memory task and an inhibition task whilst undergoing a functional magnetic resonance imaging (fMRI) scan. Task related and resting-state fMRI data from 22 women and 24 men were analysed to investigate changes in task activations and functional connectivity associated with perceived stress over the past month. Analyses were stratified by gender due to gender differences in the stress response. Stress was associated with faster working memory response time in women, but not men. Stress was not associated with any differences in task activations in either gender. There were many significant associations between stress and connectivity: findings in women were consistent with increased emotional regulation; men exhibited decreases in connectivity between affective processing areas during the tasks and showed no relation between perceived stress and resting-state connectivity; very few of the within gender differences were significantly different between gender. Dysregulated connectivity between areas involved in the neural stress response and self-referential thoughts (e.g. the default mode network) suggests that perceived stress may have a subtle impact on cognitive processing and neural correlates.
URI: https://hdl.handle.net/10356/85134
http://hdl.handle.net/10220/43645
ISSN: 2352-2895
DOI: 10.1016/j.ynstr.2017.01.002
Rights: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles
LKCMedicine Journal Articles

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