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Title: Cenderitide-eluting film for potential cardiac patch applications
Authors: Boey, Freddy Yin Chiang
Ng, Xu Wen.
Huang, Yingying.
Chen, Horng H.
Burnett Jr, John C.
Venkatraman, Subbu S.
Keywords: DRNTU::Engineering::Materials
Issue Date: 2013
Source: Ng, X. W., Huang, Y., Chen, H. H., Burnett Jr, J. C., Boey, F. Y. C.,& Venkatraman, S. S. (2013). Cenderitide-eluting film for potential cardiac patch applications. PLoS ONE, 8(7), e68346.
Series/Report no.: PLoS ONE
Abstract: Cenderitide, also known as CD-NP, is a designer peptide developed by combining native mammalian c-type natriuretic peptide (CNP) and the C-terminus isolated from the dendroapis natriuretic peptide (DNP) of the venom from the green mamba. In early studies, intravenous and subcutaneous infusion of cenderitide was reported to reduce left ventricular (LV) mass and ameliorate cardiac remodelling. In this work, biodegradable polymeric films encapsulating CD-NP were developed and were investigated for their in vitro release and degradation characteristics. Subsequently, the bioactivity of released peptide and its effects on human cardiac fibroblast (HCF) were explored. We achieved sustained release from three films with low, intermediate and high release profiles for 30 days. Moreover, the bioactivity of released peptide was verified from the elevated production of cyclic guanosine monophospate (cGMP). The CD-NP released from films was able to inhibit the proliferation of hypertrophic HCF as well as suppress DNA synthesis in HCF. Furthermore, the sustained delivery from films showed comparable or superior suppressive actions on hypertrophic HCF compared to daily infusion of CD-NP. The results suggest that these films could be used to inhibit fibrosis and reduce cardiac remodelling via local delivery as cardiac patches.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0068346
Rights: © 2013 Ng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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