Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85402
Title: Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser
Authors: Liu, Bei
Li, Chunxia
Chen, Guanying
Liu, Bin
Deng, Xiaoran
Wei, Yi
Xia, Jun
Xing, Bengang
Ma, Ping'an
Lin, Jun
Keywords: 808 nm
Bioimaging
DRNTU::Science::Chemistry
Issue Date: 2017
Source: Liu, B., Li, C., Chen, G., Liu, B., Deng, X., Wei, Y., . . . Lin, J. (2017). Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser. Advanced Science, 4(8), 1600540-. doi:10.1002/advs.201600540
Series/Report no.: Advanced Science
Abstract: Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS2@Fe3O4‐ICG/Pt(IV) (labeled as Mo@Fe‐ICG/Pt) is designed by covalently grafting Fe3O4 nanoparticles with polyethylenimine (PEI) functionalized MoS2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS2@Fe3O4. The resulting Mo@Fe‐ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future.
URI: https://hdl.handle.net/10356/85402
http://hdl.handle.net/10220/48219
DOI: 10.1002/advs.201600540
Rights: © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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