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Title: An organic afterglow protheranostic nanoassembly
Authors: He, Shasha
Xie, Chen
Jiang, Yuyan
Pu, Kanyi
Keywords: Optical Imaging
Cancer Theranostics
Engineering::Chemical engineering
Issue Date: 2019
Source: He, S., Xie, C., Jiang, Y., & Pu, K. (2019). An organic afterglow protheranostic nanoassembly. Advanced Materials, 31(32), 1902672-. doi:10.1002/adma.201902672
Series/Report no.: Advanced Materials
Abstract: Cancer theranostics holds potential promise for precision medicine; however, most existing theranostic nanoagents are simply developed by doping both therapeutic agents and imaging agent into one particle entity, and thus have an “always‐on” pharmaceutical effect and imaging signals regardless of their in vivo location. Herein, the development of an organic afterglow protheranostic nanoassembly (APtN) that specifically activates both the pharmaceutical effect and diagnostic signals in response to a tumor‐associated chemical mediator (hydrogen peroxide, H2O2) is reported. APtN comprises an amphiphilic macromolecule and a near‐infrared (NIR) dye acting as the H2O2‐responsive afterglow prodrug and the afterglow initiator, respectively. Such a molecular architecture allows APtN to passively target tumors in living mice, specifically release the anticancer drug in the tumor, and spontaneously generate the uncaged afterglow substrate. Upon NIR light preirradiation, the afterglow initiator generates singlet oxygen to react and subsequently transform the uncaged afterglow substrate into an active self‐luminescent form. Thus, the intensity of generated afterglow luminescence is correlated with the drug release status, permitting real‐time in vivo monitoring of prodrug activation. This study proposes a background‐free design strategy toward activatable cancer theranostics.
ISSN: 0935-9648
DOI: 10.1002/adma.201902672
Rights: This is the peer reviewed version of the following article: He, S., Xie, C., Jiang, Y., & Pu, K. (2019). An organic afterglow protheranostic nanoassembly. Advanced Materials, 31(32), 1902672-., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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