Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85476
Title: Unimolecular Micelles of Amphiphilic Cyclodextrin-Core Star-Like Copolymers with Covalent pH-Responsive Linkage of Anticancer Prodrugs
Authors: Jia, Tao
Huang, Shuo
Yang, Cangjie
Wang, Mingfeng
Keywords: Copolymer
Cyclodextrin
Issue Date: 2016
Source: Jia, T., Huang, S., Yang, C., & Wang, M. (2017). Unimolecular Micelles of Amphiphilic Cyclodextrin-Core Star-Like Copolymers with Covalent pH-Responsive Linkage of Anticancer Prodrugs. Molecular Pharmaceutics, 14(8), 2529-2537.
Series/Report no.: Molecular Pharmaceutics
Abstract: Multifunctional stable and stimuli-responsive drug delivery systems are important for efficient cancer treatment due to their advantages such as enhanced cancer-targeting efficiency, improved pharmacokinetics, minimized drug leaching, and reduced undesirable side effects. Here we report a robust and pH-responsive anticancer drug delivery system based on unimolecular micelles of star-like amphiphilic copolymers. The polymers (denoted as CPOFs) were facilely synthesized via one-step atom transfer radical polymerization of functionalizable benzoaldehyde and hydrophilic poly[(oligo ethylene glycol) methyl ether methacrylate] as comonomers from the core of heptakis [2,3,6-tri-o-(2-bromo-2-methyl propionyl]-β-cyclodextrin as the initiator. Doxorubicin (DOX) as an anticancer drug was covalently linked to the benzoaldehyde groups of CPOFs through pH-sensitive Schiff-base bonds. The DOX-conjugated polymers, denoted as CPOF–DOX, formed robust unimolecular micelles with an average diameter of 18 nm in aqueous media. More importantly, these unimolecular micelles showed higher drug loading capacity and more controllable drug release characteristics, compared to our previous unimolecular micelles of β-cyclodextrin-poly(lactic acid)-b-poly[(oligo ethylene glycol) methyl ether methacrylates] that physically encapsulated DOX via hydrophobic interaction. Moreover, the CPOF–DOX unimolecular micelles could be internalized by human cervical cancer HeLa cells in a stepwise way and showed less cytotoxicity compared to carrier-free DOX. We foresee that CPOF–DOX would provide a promising robust and controllable anticancer drug delivery system for future animal study and clinical trials for cancer treatment.
URI: https://hdl.handle.net/10356/85476
http://hdl.handle.net/10220/43722
ISSN: 1543-8384
DOI: 10.1021/acs.molpharmaceut.6b00708
Rights: © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular Pharmaceutics, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.molpharmaceut.6b00708].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

SCOPUSTM   
Citations 20

27
checked on Sep 5, 2020

WEB OF SCIENCETM
Citations 20

29
checked on Oct 24, 2020

Page view(s) 20

185
checked on Oct 24, 2020

Download(s) 20

88
checked on Oct 24, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.