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Title: Effect of Supercritical Carbon Dioxide Extraction Parameters on the Biological Activities and Metabolites Present in Extracts from Arthrospira platensis
Authors: Chen, Wei Ning
Esquivel-Hernández, Diego A.
Rodríguez-Rodríguez, José
Cuéllar-Bermúdez, Sara P.
García-Pérez, J. Saúl
Mancera-Andrade, Elena I.
Núñez-Echevarría, Jade E.
Ontiveros-Valencia, Aura
Rostro-Alanis, Magdalena
García-García, Rebeca M.
Antonio Torres, J.
Parra-Saldívar, Roberto
Keywords: Supercritical fluid extraction
Arthrospira platensis
Issue Date: 2017
Source: Esquivel-Hernández, D. A., Rodríguez-Rodríguez, J., Cuéllar-Bermúdez, S. P., García-Pérez, J. S., Mancera-Andrade, E. I., Núñez-Echevarría, J. E., et al. (2017). Effect of Supercritical Carbon Dioxide Extraction Parameters on the Biological Activities and Metabolites Present in Extracts from Arthrospira platensis. Marine Drugs, 15(6), 174-.
Series/Report no.: Marine Drugs
Abstract: Arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO2). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett–Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0.10 µg/g of β-carotene, 1.44 ± 0.10 µg/g of lutein and 32.11 ± 0.12 mg/g of fatty acids with 39.38% of palmitic acid, 20.63% of linoleic acid and 30.27% of γ-linolenic acid. A. platensis extracts had an antioxidant activity of 76.47 ± 0.71 µg GAE/g by Folin–Ciocalteu assay, 0.52 ± 0.02, 0.40 ± 0.01 and 1.47 ± 0.02 µmol TE/g by DPPH, FRAP and TEAC assays, respectively. These extracts showed antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231. Overall, co-solvent was the most significant factor for all measured effects (p < 0.05). Arthrospira platensis represents a sustainable source of bioactive compounds through SFE using the following extraction parameters P: 450 bar, CX: 11 g/min, SX: 15 min, DX: 25 min, T: 60 °C and Di: 35 g.
ISSN: 1660-3397
DOI: 10.3390/md15060174
Rights: © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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