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dc.contributor.authorShi, Yuzhien
dc.contributor.authorXiong, Shaen
dc.contributor.authorChin, Lip Keten
dc.contributor.authorZhang, Jingboen
dc.contributor.authorSer, Weeen
dc.contributor.authorWu, Jiuhuien
dc.contributor.authorChen, Tianningen
dc.contributor.authorYang, Zhenchuanen
dc.contributor.authorHao, Yilongen
dc.contributor.authorLiedberg, Boen
dc.contributor.authorYap, Peng Huaten
dc.contributor.authorTsai, Din Pingen
dc.contributor.authorQiu, Cheng-Weien
dc.contributor.authorLiu, Ai Qunen
dc.identifier.citationShi, Y., Xiong, S., Chin, L. K., Zhang, J., Ser, W., Wu, J., et al. (2018). Nanometer-precision linear sorting with synchronized optofluidic dual barriers. Science Advances, 4(1), eaao0773-.en
dc.description.abstractThe past two decades have witnessed the revolutionary development of optical trapping of nanoparticles, most of which deal with trapping stiffness larger than 10−8 N/m. In this conventional regime, however, it remains a formidable challenge to sort out sub–50-nm nanoparticles with single-nanometer precision, isolating us from a rich flatland with advanced applications of micromanipulation. With an insightfully established roadmap of damping, the synchronization between optical force and flow drag force can be coordinated to attempt the loosely overdamped realm (stiffness, 10−10 to 10−8 N/m), which has been challenging. This paper intuitively demonstrates the remarkable functionality to sort out single gold nanoparticles with radii ranging from 30 to 50 nm, as well as 100- and 150-nm polystyrene nanoparticles, with single nanometer precision. The quasi-Bessel optical profile and the loosely overdamped potential wells in the microchannel enable those aforementioned nanoparticles to be separated, positioned, and microscopically oscillated. This work reveals an unprecedentedly meaningful damping scenario that enriches our fundamental understanding of particle kinetics in intriguing optical systems, and offers new opportunities for tumor targeting, intracellular imaging, and sorting small particles such as viruses and DNA.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.format.extent8 p.en
dc.relation.ispartofseriesScience Advancesen
dc.rights© 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.en
dc.subjectNanometer Precisionen
dc.subjectOptofluidic Dual Barriersen
dc.titleNanometer-precision linear sorting with synchronized optofluidic dual barriersen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.researchCentre for Biomimetic Sensor Scienceen
dc.description.versionPublished versionen
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