Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85549
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dc.contributor.authorEro, Ryaen
dc.contributor.authorKumar, Veerendraen
dc.contributor.authorChen, Yunen
dc.contributor.authorGao, Yong-Guien
dc.date.accessioned2017-09-12T07:35:08Zen
dc.date.accessioned2019-12-06T16:05:49Z-
dc.date.available2017-09-12T07:35:08Zen
dc.date.available2019-12-06T16:05:49Z-
dc.date.issued2016en
dc.identifier.citationEro, R., Kumar, V., Chen, Y., & Gao, Y.-G. (2016). Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to function. RNA Biology, 13(12), 1258-1273.en
dc.identifier.issn1547-6286en
dc.identifier.urihttps://hdl.handle.net/10356/85549-
dc.description.abstractEF-G, EF4, and BipA are members of the translation factor family of GTPases with a common ribosome binding mode and GTPase activation mechanism. However, topological variations of shared as well as unique domains ensure different roles played by these proteins during translation. Recent X-ray crystallography and cryo-electron microscopy studies have revealed the structural basis for the involvement of EF-G domain IV in securing the movement of tRNAs and mRNA during translocation as well as revealing how the unique C-terminal domains of EF4 and BipA interact with the ribosome and tRNAs contributing to the regulation of translation under certain conditions. EF-G, EF-4, and BipA are intriguing examples of structural variations on a common theme that results in diverse behavior and function. Structural studies of translational GTPase factors have been greatly facilitated by the use of antibiotics, which have revealed their mechanism of action.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent16 p.en
dc.language.isoenen
dc.relation.ispartofseriesRNA Biologyen
dc.rights© 2016 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.en
dc.subjectBipAen
dc.subjectEF-Gen
dc.titleSimilarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to functionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1080/15476286.2016.1201627en
dc.description.versionPublished versionen
item.grantfulltextopen-
item.fulltextWith Fulltext-
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