Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85590
Title: Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients
Authors: Wongsurawat, Thidathip
Woo, Chin Cheng
Giannakakis, Antonis
Lin, Xiao Yun
Cheow, Esther Sok Hwee
Lee, Chuen Neng
Richards, Mark
Sze, Siu Kwan
Nookaew, Intawat
Sorokin, Vitaly
Kuznetsov, Vladimir Andreevich
Keywords: Genomics
Proteomics
Issue Date: 2018
Source: Wongsurawat, T., Woo, C. C., Giannakakis, A., Lin, X. Y., Cheow, E. S. H., Lee, C. N., et al. (2018). Transcriptome alterations of vascular smooth muscle cells in aortic wall of myocardial infarction patients. Data in Brief, 17, 1112-1135.
Series/Report no.: Data in Brief
Abstract: This article contains further data and information from our published manuscript [1]. We aim to identify significant transcriptome alterations of vascular smooth muscle cells (VSMCs) in the aortic wall of myocardial infarction (MI) patients. Microarray gene analysis was applied to evaluate VSMCs of MI and non-MI patients. Prediction Analysis of Microarray (PAM) identified genes that significantly discriminated the two groups of samples. Incorporation of gene ontology (GO) identified a VSMCs-associated classifier that discriminated between the two groups of samples. Mass spectrometry-based iTRAQ analysis revealed proteins significantly differentiating these two groups of samples. Ingenuity Pathway Analysis (IPA) revealed top pathways associated with hypoxia signaling in cardiovascular system. Enrichment analysis of these proteins suggested an activated pathway, and an integrated transcriptome-proteome pathway analysis revealed that it is the most implicated pathway. The intersection of the top candidate molecules from the transcriptome and proteome highlighted overexpression.
URI: https://hdl.handle.net/10356/85590
http://hdl.handle.net/10220/45184
ISSN: 2352-3409
DOI: 10.1016/j.dib.2018.01.108
Rights: © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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