Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85636
Title: Ultrahigh-resolution OCT imaging of the human cornea
Authors: Werkmeister, René M.
Sapeta, Sabina
Schmidl, Doreen
Garhöfer, Gerhard
Schmidinger, Gerald
Aschinger, Gerold C.
Baumgartner, Isabella
Pircher, Niklas
Schwarzhans, Florian
Pantalon, Anca
Dua, Harminder
Schmetterer, Leopold
Santos, Valentin Aranha Dos
Keywords: Imaging Systems
Ophthalmic Optics And Devices
DRNTU::Science::Medicine
Issue Date: 2017
Source: Werkmeister, R. M., Sapeta, S., Schmidl, D., Garhöfer, G., Schmidinger, G., Santos, V. A. D., . . . Schmetterer, L. (2017). Ultrahigh-resolution OCT imaging of the human cornea. Biomedical Optics Express, 8(2), 1221-1239. doi:10.1364/BOE.8.001221
Series/Report no.: Biomedical Optics Express
Abstract: We present imaging of corneal pathologies using optical coherence tomography (OCT) with high resolution. To this end, an ultrahigh-resolution spectral domain OCT (UHR-OCT) system based on a broad bandwidth Ti:sapphire laser is employed. With a central wavelength of 800 nm, the imaging device allows to acquire OCT data at the central, paracentral and peripheral cornea as well as the limbal region with 1.2 µm x 20 µm (axial x lateral) resolution at a rate of 140 000 A-scans/s. Structures of the anterior segment of the eye, not accessible with commercial OCT systems, are visualized. These include corneal nerves, limbal palisades of Vogt as well as several corneal pathologies. Cases such as keratoconus and Fuchs’s endothelial dystrophy as well as infectious changes caused by diseases like Acanthamoeba keratitis and scarring after herpetic keratitis are presented. We also demonstrate the applicability of our system to visualize epithelial erosion and intracorneal foreign body after corneal trauma as well as chemical burns. Finally, results after Descemet’s membrane endothelial keratoplasty (DMEK) are imaged. These clinical cases show the potential of UHR-OCT to help in clinical decision-making and follow-up. Our results and experience indicate that UHR-OCT of the cornea is a promising technique for the use in clinical practice, but can also help to gain novel insight in the physiology and pathophysiology of the human cornea.
URI: https://hdl.handle.net/10356/85636
http://hdl.handle.net/10220/48227
DOI: 10.1364/BOE.8.001221
Rights: © 2017 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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