Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/85711
Title: Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective
Authors: Koo, Carmen
Tien, Wei Ping
Xu, Helen
Ong, Janet
Rajarethinam, Jayanthi
Lai, Yee Ling
Ng, Lee-Ching
Hapuarachchi, Hapuarachchige Chanditha
Keywords: Disease
Virology
Science::Biological sciences
Issue Date: 2018
Source: Koo, C., Tien, W. P., Xu, H., Ong, J., Rajarethinam, J., Lai, Y. L., . . . Hapuarachchi, H. C. (2018). Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective. iScience, 6, 38-51. doi:10.1016/j.isci.2018.07.008
Series/Report no.: iScience
Abstract: Arbovirus transmission is modulated by host, vector, virus, and environmental factors. Even though viral fitness plays a salient role in host and vector adaptation, the transmission success of individual strains in a heterogeneous population may be stochastic. Our large-scale molecular epidemiological analyses of a dengue virus type 1 population revealed that only a subset of strains (16.7%; n = 6) were able to sustain transmission, despite the population being widely dispersed, dynamic, and heterogeneous. The overall dominance was variable even among the “established” lineages, albeit sharing comparable evolutionary characteristics and replication profiles. These findings indicated that virological parameters alone were unlikely to have a profound effect on the survival of viral lineages, suggesting an important role for non-viral factors in the transmission success of lineages. Our observations, therefore, emphasize the strategic importance of a holistic understanding of vector, human host, and viral factors in the control of vector-borne diseases.
URI: https://hdl.handle.net/10356/85711
http://hdl.handle.net/10220/49841
DOI: 10.1016/j.isci.2018.07.008
Rights: © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

SCOPUSTM   
Citations 20

3
checked on Sep 5, 2020

WEB OF SCIENCETM
Citations 20

2
checked on Oct 26, 2020

Page view(s) 20

23
checked on Oct 30, 2020

Download(s) 20

10
checked on Oct 30, 2020

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.