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Title: A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases
Authors: Lim, Wei Shan
Chen, Kenneth
Chong, Tsung Wen
Xiong, Gordon Minru
Birch, William R.
Pan, Jisheng
Lee, Bae Hoon
Er, Pei Shan
Salvekar, Abhijit Vijay
Venkatraman, Subbu S.
Huang, Yingying
Keywords: DRNTU::Engineering::Materials
Urological Diseases
Drug-Eluting Stent
Issue Date: 2018
Source: Lim, W. S., Chen, K., Chong, T. W., Xiong, G. M., Birch, W. R., Pan, J., . . . Huang, Y. (2018). A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases. Biomaterials, 165, 25-38. doi:10.1016/j.biomaterials.2018.02.035
Series/Report no.: Biomaterials
Abstract: A bilayer swellable drug-eluting ureteric stent (BSDEUS) is engineered and implemented, as a sustained drug delivery platform technology that enhances localized drug delivery to the highly impermeable urothelium, for the treatment of urothelial diseases such as strictures and carcinomas. On deployment, the device swells to co-apt with the ureteric wall and ensure drug availability to these tissues. BSDEUS consists of a stent spray-coated with a polymeric drug containing polylactic acid-cocaprolactone (PLC) layer which is overlaid by a swellable polyethylene glycol diacrylate (PEGDA) based hydrogel. In-vitro quantification of released drug demonstrated a tunable time-profile, indicating sustained delivery over 1-month. The PEGDA hydrogel overlayer enhanced drug release and transport into explanted porcine ureteric tissues ex-vivo, under a simulated dynamic fluid flow. A preliminary pilot invivo feasibility study, in a porcine model, demonstrated that the swollen hydrogel co-apts with the urothelium and thus enables localized drug delivery to the target tissue section. Kidney functions remained unaffected and device did not result in either hydronephrosis or systemic toxicity. This successful engineering of a bilayer coated stent prototype, demonstrates its feasibility, thus offering a unique solution for drug-based urological therapy.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2018.02.035
Rights: © 2018 Elsevier. All rights reserved. This paper was published in Biomaterials and is made available with permission of Elsevier.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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