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Title: Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
Authors: Sivasubramanian, Kathyayini
Periyasamy, Vijitha
Pramanik, Manojit
Keywords: Photoacoustic imaging
Small animal imaging
Issue Date: 2017
Source: Sivasubramanian, K., Periyasamy, V., & Pramanik, M. (2017). Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging. Journal of Visualized Experiments, (128), e56649-.
Series/Report no.: Journal of Visualized Experiments
Abstract: Translation of photoacoustic imaging into the clinic is a major challenge. Handheld real-time clinical photoacoustic imaging systems are very rare. Here, we report a combined photoacoustic and clinical ultrasound imaging system by integrating an ultrasound probe with light delivery for small animal imaging. We demonstrate this by showing sentinel lymph node imaging in small animals along with minimally invasive real-time needle guidance. A clinical ultrasound platform with access to raw channel data allows the integration of photoacoustic imaging leading to a handheld real-time clinical photoacoustic imaging system. Methylene blue was used for sentinel lymph node imaging at 675 nm wavelength. Additionally, needle guidance with dual modal ultrasound and photoacoustic imaging was shown using the imaging system. Depth imaging of up to 1.5 cm was demonstrated with a 10 Hz laser at a photoacoustic imaging frame rate of 5 frames per second.
DOI: 10.3791/56649
Rights: © 2017 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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