Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/86020
Title: Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension
Authors: Chua, Jacqueline
Chin, Calvin Woon Loong
Tan, Bingyao
Wong, Si Han
Devarajan, Kavya
Le, Thu-Thao
Ang, Marcus
Wong, Tien Yin
Schmetterer, Leopold
Keywords: DRNTU::Science::Medicine
Diseases
Medical Research
Issue Date: 2019
Source: Chua, J., Chin, C. W. L., Tan, B., Wong, S. H., Devarajan, K., Le, T.-T., & Schmetterer, L. (2019). Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension. Scientific Reports, 9, 5819-. doi:10.1038/s41598-019-41917-4
Series/Report no.: Scientific Reports
Abstract: We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to investigate the association of systemic risk factors with area (percentage), size (pixels) and number of choriocapillaris flow voids. Diabetes (β = 0.33; 95% CI, 0.02 to 0.63) and daytime systolic BP (β = −0.13; 95% CI, −0.24 to −0.02) were associated with areas of flow voids. Age (β = 0.21; 95% CI, 0.06 to 0.36) and daytime diastolic BP (β = −0.18; 95% CI, −0.34 to −0.02) were associated with size of flow voids. Age (β = −21.21; 95% CI, −31.79 to −10.63) and nighttime diastolic BP (β = 13.89; 95% CI, 0.61 to 27.17) were associated with number of flow voids. Kidney parameters were not associated with any features of flow voids. In patients with hypertension, a higher BP appeared to increase blood flow in the choriocapillaris which needs to be considered when using the OCTA to study eye diseases in hypertensives.
URI: https://hdl.handle.net/10356/86020
http://hdl.handle.net/10220/48280
DOI: 10.1038/s41598-019-41917-4
Rights: © 2019 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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