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Title: Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders
Authors: Cataldo, Ilaria
Azhari, Atiqah
Lepri, Bruno
Esposito, Gianluca
Keywords: Gene-environment interaction
Issue Date: 2017
Source: Cataldo, I., Azhari, A., Lepri, B., & Esposito, G. (2017). Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders. Research in Developmental Disabilities, in press.
Series/Report no.: Research in Developmental Disabilities
Abstract: Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword “OXTR” before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total. The papers were catalogued in a database and filtered for gene-environment interaction, psychiatric disorders and involvement of parental care. In particular, rs53576 and rs2254298 were found to be significantly involved in gene-environment interactions that modulated risk for psychopathology and the following psychiatric disorders: disruptive behavior, depression, anxiety, eating disorder and borderline personality disorder. These results illustrate the importance of OXTR in mediating the impact of parental care on the emergence of psychopathology.
ISSN: 0891-4222
DOI: 10.1016/j.ridd.2017.10.007
Rights: © 2017 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Research in Developmental Disabilities, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles


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