Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/86085
Title: Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior
Authors: Kim, Bokyeong
Yoon, Sehyoun
Nakajima, Ryuichi
Lee, Hyo Jin
Lim, Hee Jeong
Lee, Yeon-Kyung
Choi, June-Seek
Yoon, Bong-June
Augustine, George James
Baik, Ja-Hyun
Keywords: Dopamine Receptor
Impulsivity
Science::Biological sciences::Human anatomy and physiology::Neurobiology
Issue Date: 2018
Source: Kim, B., Yoon, S., Nakajima, R., Lee, H. J., Lim, H. J., Lee, Y.-K., . . . Baik, J.-H. (2018). Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior. Proceedings of the National Academy of Sciences, 115(45), E10730-E10739. doi:10.1073/pnas.1811664115
Series/Report no.: Proceedings of the National Academy of Sciences
Abstract: Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We found that the absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala (CeA) of D2R knockout mice (Drd2−/−) normalized their enhanced impulsivity. Inhibitory synaptic output from D2R-expressing neurons in the CeA underlies modulation of impulsive behavior because optogenetic activation of D2R-positive inhibitory neurons that project from the CeA to the bed nucleus of the stria terminalis (BNST) attenuate such behavior. Our identification of the key contribution of D2R-expressing neurons in the CeA → BNST circuit to the control of impulsive behavior reveals a pathway that could serve as a target for approaches to the management of neuropsychiatric disorders associated with impulsivity.
URI: https://hdl.handle.net/10356/86085
http://hdl.handle.net/10220/49852
ISSN: 0027-8424
DOI: 10.1073/pnas.1811664115
Rights: © 2018 The Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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