Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/86101
Title: Palladium-catalyzed enantioselective arylation of racemic ketones to form bridged bicycles via dynamic kinetic resolution
Authors: Huang, Xiaolei
Oh, William Ray Jun Jie
Zhou, Steve Jianrong
Keywords: Alkylation
DRNTU::Science::Chemistry
Palladium Catalysis
Issue Date: 2018
Source: Huang, X., Oh, W. R. J. J., & Zhou, S. J. (2018). Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Angewandte Chemie International Edition, 57(26), 7673-7677. doi:10.1002/anie.201804318
Series/Report no.: Angewandte Chemie International Edition
Abstract: Enantioselective α‐arylation of racemic ketones containing existing α′‐stereocenters is reported for the first time via base‐induced dynamic kinetic resolution. Bridged bicyclic rings are formed in good ee values, which are difficult to obtain otherwise. Furthermore, reactions in DMSO‐d6 resulted in extensive deuteration of both α‐ and α′‐positions in the products, thus supporting a pathway involving rapid, reversible deprotonation of ketones under catalytic conditions.
URI: https://hdl.handle.net/10356/86101
http://hdl.handle.net/10220/48295
ISSN: 1433-7851
DOI: 10.1002/anie.201804318
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Huang, X., Oh, W. R. J. J., & Zhou, S. J. (2018). Palladium-Catalyzed Enantioselective Arylation of Racemic Ketones to Form Bridged Bicycles via Dynamic Kinetic Resolution. Angewandte Chemie International Edition, 57(26), 7673-7677, which has been published in final form at http://dx.doi.org/10.1002/anie.201804318. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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