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dc.contributor.authorZhuang, Peien
dc.contributor.authorSun, Alfred Xuyangen
dc.contributor.authorAn, Jiaen
dc.contributor.authorChua, Chee Kaien
dc.contributor.authorChew, Sing Yianen
dc.identifier.citationZhuang, P., Sun, A. X., An, J., Chua, C. K., & Chew, S. Y. (2018). 3D neural tissue models : from spheroids to bioprinting. Biomaterials, 154113-133. doi:10.1016/j.biomaterials.2017.10.002en
dc.description.abstractThree-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.format.extent52 p.en
dc.rights© 2018 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subject3D Printingen
dc.subjectNerve Regenerationen
dc.subjectDRNTU::Engineering::Mechanical engineeringen
dc.title3D neural tissue models : from spheroids to bioprintingen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.organizationA*STAR Genome Institute of Singaporeen
dc.contributor.researchSingapore Centre for 3D Printingen
dc.description.versionAccepted versionen
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MAE Journal Articles
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