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Title: 3D neural tissue models : from spheroids to bioprinting
Authors: Zhuang, Pei
Sun, Alfred Xuyang
An, Jia
Chua, Chee Kai
Chew, Sing Yian
Keywords: 3D Printing
Nerve Regeneration
DRNTU::Engineering::Mechanical engineering
Issue Date: 2018
Source: Zhuang, P., Sun, A. X., An, J., Chua, C. K., & Chew, S. Y. (2018). 3D neural tissue models : from spheroids to bioprinting. Biomaterials, 154113-133. doi:10.1016/j.biomaterials.2017.10.002
Series/Report no.: Biomaterials
Abstract: Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2017.10.002
Schools: School of Chemical and Biomedical Engineering 
School of Mechanical and Aerospace Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: A*STAR Genome Institute of Singapore
Research Centres: Singapore Centre for 3D Printing 
Rights: © 2018 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
MAE Journal Articles
SCBE Journal Articles

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